Inhibition of Glycogen Synthase Kinase and the Neuroprotective Function of Conjugated ZnO-Osthol Nanoparticles in Alzheimer’s Disease

A critical factor in the cause and progression of Alzheimer’s disease (AD) is growth ?-amyloid peptide (A?) brain. The mechanism this effect still unknown, although osthol on A?-induced inflammation neuroprotective AD supplementation with zinc might prevent or delay onset dementia. In current study, by inducing APP vector human BE (2)-M17 cells, we established a cellular model investigated protective (7-methoxy-8-3-methyl-2-butenyl-2H-1-benzopyran-2-one)-zinc oxide nanoparticles. osthol-conjugated nanoparticles could significantly increase cell viability inhibiting apoptosis. Osthol treatment has also prevented synaptic proteins such as postsynaptic density-95 (PSD-95), synaptophysin (SYP), synapsin-1 from decreasing APP-induced cells. addition, expression miR-132 was upregulated triggering Wnt/?-catenin signaling pathway. We conclude our observations that potential drug for neurodegenerative disease, Alzheimer’s. key reason upregulating miR-132, inhibit to occurring.